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Searching for the Philosopher's Stone, alchemy brothers Edward and Alphonse Elric become obsessed with bringing their mother back to life. After an illness takes her, these boys do everything to learn stronger elements of alchemy. This creates a chain reaction of negative results, some of them costing the brothers their body parts.
In order to become normal again, Edward and Alphonse must become state alchemist. Edward's knowledge grows, which eventually lands him being employed by the SMA (State Military of Amestris), but it's the only way to locate the Philosopher's Stone. If they find it, there is a possibility their bodies will be put back piece by piece.
However, they're not the only ones looking for this ancient artifact. There are several dangers throughout their journey, but it's a story that will keep you rooting for these two underdogs.